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The antibody against L3MBTL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human L3MBTL3 (NP_115814.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
The antibody against L3MBTL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human L3MBTL3 (NP_115814.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
| Cat.No | ADA-14681A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | L3MBTL3 |
| Target Synonyms | MBT1; MBT-1; L3MBTL3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293F | Application | ELISA, WB, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human L3MBTL3 (NP_115814.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96JM7 | Immunogen Sequence |
Uniprot Id
Q96JM7
Target Species
Human
Target Name
L3MBTL3
Target Full Name
Lethal(3)malignant brain tumor-like protein 3
Target Function
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells.
Target Subcellular Location
Nucleus.
Target Synonyms
L3MBTL3; H-l(3)mbt-like protein 3; Hl(3)mbt like protein; KIAA1798; l(3)mbt like 3 (Drosophila); l(3)mbt like 3; L(3)mbt like 3 protein; L(3)mbt-like protein 3; L3mbtl3; Lethal(3)malignant brain tumor like 3 protein; Lethal(3)malignant brain tumor-like protein 3; LMBL3_HUMAN; MBT-1; MBT1; RP11-73O6.1
Target Background
This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma.
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