Rabbit anti-Human RARG Monoclonal Antibody

Uniprot Id

P13631

Target Species

Human

Target Name

RARG

Target Full Name

Retinoic acid receptor gamma

Target Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

Nuclear hormone receptor family, NR1 subfamily

Target Tissue Specificity

Expressed in aortic endothelial cells (at protein level).

Target Synonyms

NR1B3; Nuclear receptor subfamily 1 group B member 3; RAR gamma; RAR gamma isoform 2; RAR gamma2; RAR-gamma; RARC; Rarg; RARG_HUMAN; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor gamma

Target Background

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.