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The antibody against CDA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA(NP_001776.1?) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, FC, ELISA.
The antibody against CDA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA(NP_001776.1?) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, FC, ELISA.
Immunohistochemistry analysis of CDA in paraffin-embedded human spleen using CDA Rabbit mAb at dilution of 1:1000 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
| Cat.No | ADA-15535A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDA |
| Target Synonyms | CDD; CDA | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, PC-3, U-937 | Application | ELISA, FC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA(NP_001776.1?). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ | Uniprot ID | P32320 |
Uniprot Id
P32320
Target Species
Human
Target Name
CDA
Target Full Name
Cytidine deaminase
Target Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Target Protein Families
Cytidine and deoxycytidylate deaminase family
Target Tissue Specificity
Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
CDA; CDDCytidine deaminase; EC 3.5.4.5; Cytidine aminohydrolase
Target Background
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
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