Rabbit anti-Human SDPR/Cavin-2 Monoclonal Antibody

Uniprot Id

O95810

Target Species

Human

Target Name

CAVIN2

Target Full Name

Caveolae-associated protein 2

Target Function

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae.

Target Subcellular Location

Cytoplasm, cytosol. Membrane, caveola.

Target Protein Families

CAVIN family

Target Tissue Specificity

Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.

Target Synonyms

Cavin 2; Cavin-2; Phosphatidylserine binding protein; Phosphatidylserine-binding protein; PS p68; PS-p68; Sdpr; SDPR_HUMAN; SDR; Serum deprivation response ; Serum deprivation response protein; Serum deprivation-response protein

Target Background

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.