Rabbit anti-Human ACLY Monoclonal Antibody

The antibody against ACLY was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1000-1101 of human ACLY (P53396) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.

ADA-16578A

Number

Cat.No	ADA-16578A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	ACLY
Target Synonyms	ACL; ATPCL; CLATP; ACLY	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Hep G2, Jurkat, Mouse brain, Mouse liver, Mouse lung, Rat liver, Rat lung	Application	ELISA, WB, IF/ICC, IP

Cat.No

ADA-16578A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

ACLY

Target Synonyms

ACL; ATPCL; CLATP; ACLY

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Hep G2, Jurkat, Mouse brain, Mouse liver, Mouse lung, Rat liver, Rat lung

Application

ELISA, WB, IF/ICC, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1000-1101 of human ACLY (P53396).	Target Species	Human
Immunogen Sequence	ATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM	Uniprot ID	P53396

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1000-1101 of human ACLY (P53396).

Target Species

Human

Immunogen Sequence

ATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM

Uniprot ID

P53396

Background Information

Uniprot Id

P53396
Target Species

Human
Target Name

ACLY
Target Full Name

ATP-citrate synthase
Target Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
Target Subcellular Location

Cytoplasm, cytosol.
Target Protein Families

Succinate/malate CoA ligase beta subunit family; Succinate/malate CoA ligase alpha subunit family
Target Research Area

Metabolism
Target Synonyms

ACL; Acly; ACLY_HUMAN; ATP citrate (pro-S) lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; ATPcitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773
Target Background

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Rabbit anti-Human ACLY Monoclonal Antibody

Specifications

Immunogen Information

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