Rabbit anti-Human CCR7 Monoclonal Antibody

The antibody against CCR7 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (P32248) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-16993A

Number

Cat.No	ADA-16993A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	CCR7
Target Synonyms	BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; CCR7	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	C6, A-549, Jurkat, Mouse lung, Mouse spleen, Rat lung	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-16993A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

CCR7

Target Synonyms

BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; CCR7

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

C6, A-549, Jurkat, Mouse lung, Mouse spleen, Rat lung

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (P32248).	Target Species	Human
Immunogen Sequence	MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNL	Uniprot ID	P32248

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (P32248).

Target Species

Human

Immunogen Sequence

MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNL

Uniprot ID

P32248

Background Information

Uniprot Id

P32248
Target Species

Human
Target Name

CCR7
Target Full Name

C-C chemokine receptor type 7
Target Function

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Target Subcellular Location

Cell membrane; Multi-pass membrane protein.
Target Protein Families

G-protein coupled receptor 1 family
Target Tissue Specificity

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Target Research Area

Others
Target Synonyms

CCR7; CMKBR7; EBI1; EVI1; C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD antigen CD197
Target Background

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.

Rabbit anti-Human CCR7 Monoclonal Antibody

Specifications

Immunogen Information

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