Rabbit anti-Human Histone H2A.Z Monoclonal Antibody

The antibody against Histone H2A.Z was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H2A.Z (P0C0S5) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ChIP, ELISA.

ADA-17181A

Number

Cat.No	ADA-17181A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Histone H2A.Z
Target Synonyms	H2AZ; H2A.z; H2A/z; H2AFZ; H2A.Z-1; .Z	Form	Liquid
Species Reactivity	Human, Mouse, Rat, Other (Wide Range Predicted)	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, Mouse brain, Mouse lung, Mouse testis, Rat lung, Rat testis, U-87MG	Application	ELISA, WB, ChIP, IP

Cat.No

ADA-17181A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Histone H2A.Z

Target Synonyms

H2AZ; H2A.z; H2A/z; H2AFZ; H2A.Z-1; .Z

Form

Liquid

Species Reactivity

Human, Mouse, Rat, Other (Wide Range Predicted)

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, Mouse brain, Mouse lung, Mouse testis, Rat lung, Rat testis, U-87MG

Application

ELISA, WB, ChIP, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H2A.Z (P0C0S5).	Target Species	Human
Immunogen Sequence	MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSL	Uniprot ID	P0C0S5

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H2A.Z (P0C0S5).

Target Species

Human

Immunogen Sequence

MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSL

Uniprot ID

P0C0S5

Background Information

Uniprot Id

P0C0S5
Target Species

Human
Target Name

H2AZ1
Target Full Name

Histone H2A.Z
Target Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Target Subcellular Location

Nucleus. Chromosome.
Target Protein Families

Histone H2A family
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

H2A histone family member Z; H2A.z; H2A/z; H2afz; H2AZ; H2AZ_HUMAN; Histone H2A.Z; MGC117173
Target Background

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

Rabbit anti-Human Histone H2A.Z Monoclonal Antibody

Specifications

Immunogen Information

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