Recombinant Human Caveolin-1 (CAV1)

Cat.No	ACP00306	Target Name	CAV1
Target Synonyms	CAV	Form	Liquid or Lyophilized powder
Expression System	in vitro E.coli expression system	Expression Range	1-178aa
Mol Weight	22	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00306

Target Name

CAV1

Target Synonyms

CAV

Form

Liquid or Lyophilized powder

Expression System

in vitro E.coli expression system

Expression Range

1-178aa

Mol Weight

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q03135

Background Information

Uniprot Id

Q03135
Target Species

Human
Target Name

CAV1
Target Full Name

Caveolin-1
Target Function

May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
Target Involvement

Congenital generalized lipodystrophy 3 (CGL3); Pulmonary hypertension, primary, 3 (PPH3); Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome (LCCNS)
Target Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
Target Protein Families

Caveolin family
Target Tissue Specificity

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.
Target Research Area

Cancer
Target Synonyms

CAV
Target Background

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Recombinant Human Caveolin-1 (CAV1)

Specifications

Immunogen Information

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