Home Products Recombinant Human E3 ubiquitin-protein ligase RNF43 (RNF43), Truncated

Recombinant Human E3 ubiquitin-protein ligase RNF43 (RNF43), Truncated

ACP00368

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Specifications

Cat.No	ACP00368	Target Name	RNF43
Target Synonyms	RING finger protein 43;RING-type E3 ubiquitin transferase RNF43	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	24-197aa
Mol Weight	26.1 kDa	Protein Length	Partial
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q68DV7

Background Information

Uniprot Id

Q68DV7
Target Species

Human
Target Name

RNF43
Target Full Name

E3 ubiquitin-protein ligase RNF43
Target Function

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
Target Involvement

Sessile serrated polyposis cancer syndrome (SSPCS)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope.
Target Protein Families

ZNRF3 family
Target Tissue Specificity

Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
Target Research Area

Cancer
Target Synonyms

RNF43; E3 ubiquitin-protein ligase RNF43; EC 2.3.2.27; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43

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Recombinant Human E3 ubiquitin-protein ligase RNF43 (RNF43), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human E3 ubiquitin-protein ligase RNF43 (RNF43), Truncated Now

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