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| Cat.No | ACP00468 | Target Name | DNASE1L2 |
|---|---|---|---|
| Target Synonyms | DNase I homolog protein DHP1;Deoxyribonuclease I-like 2;DNase I-like 2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 21-299aa |
| Mol Weight | 38.4 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q92874 |
|---|
Uniprot Id
Q92874
Target Species
Human
Target Name
DNASE1L2
Target Full Name
Deoxyribonuclease-1-like 2
Target Function
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.
Target Subcellular Location
Cytoplasm. Secreted.
Target Protein Families
DNase I family
Target Tissue Specificity
Preferentially expressed in the skin and up-regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
DNASE1L2; DHP1; DNAS1L2Deoxyribonuclease-1-like 2; EC 3.1.21.-; DNase I homolog protein DHP1; Deoxyribonuclease I-like 2; DNase I-like 2
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