Recombinant Human Vitamin K-dependent protein C(PROC)

Uniprot Id

P04070

Target Species

Human

Target Name

PROC

Target Full Name

Vitamin K-dependent protein C

Target Function

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

Target Involvement

Thrombophilia due to protein C deficiency, autosomal dominant (THPH3); Thrombophilia due to protein C deficiency, autosomal recessive (THPH4)

Target Subcellular Location

Secreted. Golgi apparatus. Endoplasmic reticulum.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

Plasma; synthesized in the liver.

Target Research Area

Others

Target Synonyms

Activation peptide; Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21.69; PC; proC; PROC_HUMAN; PROC1 ; Protein C (inactivator of coagulation factors Va and VIIIa); THPH3; THPH4; Vitamin K dependent protein C

Target Background

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.