Recombinant Human Granzyme K (GZMK)

Uniprot Id

P49863

Target Species

Human

Target Name

GZMK

Target Full Name

Granzyme K

Target Subcellular Location

Secreted. Cytoplasmic granule.

Target Protein Families

Peptidase S1 family, Granzyme subfamily

Target Tissue Specificity

Expressed in lung, spleen, thymus and peripheral blood leukocytes.

Target Research Area

Cell Biology

Target Synonyms

Fragmentin 3; Fragmentin-3; Fragmentin3; GRAK_HUMAN; Granzyme 3; granzyme K (granzyme 3; tryptase II); granzyme K (serine protease; granzyme 3; tryptase II); Granzyme K; Granzyme K precursor; Granzyme-3; Granzyme3; GranzymeK; GZMK; NK TRYP 2; NK TRYP2; NK tryptase 2; NK-TRYP-2; NK-tryptase-2; NKTRYP2; Serine protease granzyme 3; TRYP 2; TRYP2; Tryptase II; TryptaseII

Target Background

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.