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| Cat.No | ACP00593 | Target Name | DPEP1 |
|---|---|---|---|
| Target Synonyms | Beta-lactamase;Dehydropeptidase-I;Microsomal dipeptidase;Renal dipeptidase;hRDP | Form | Liquid or Lyophilized powder |
| Expression System | Mammalian cell | Expression Range | 17-385aa |
| Mol Weight | 42.8 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P16444 |
|---|
Uniprot Id
P16444
Target Species
Human
Target Name
DPEP1
Target Full Name
Dipeptidase 1
Target Function
Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics.; Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.
Target Subcellular Location
Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
Metallo-dependent hydrolases superfamily, Peptidase M19 family
Target Tissue Specificity
Expressed in lung and kidneys.
Target Research Area
Cancer
Target Synonyms
Dehydropeptidase-I; Dipeptidase 1 (renal); Dipeptidase 1; DPEP1; DPEP1_HUMAN; hRDP; MBD1; MDP; Microsomal dipeptidase; RDP; Renal dipeptidase
Target Background
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer.
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