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| Cat.No | ACP00681 | Target Name | PRDM8 |
|---|---|---|---|
| Target Synonyms | PR domain-containing protein 8 | Form | Liquid or Lyophilized powder |
| Expression System | Baculovirus | Expression Range | 1-689aa |
| Mol Weight | 74.1 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NQV8 |
|---|
Uniprot Id
Q9NQV8
Target Species
Human
Target Name
PRDM8
Target Full Name
PR domain zinc finger protein 8
Target Function
Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR. Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival.
Target Involvement
Epilepsy, progressive myoclonic 10 (EPM10)
Target Subcellular Location
Nucleus.
Target Protein Families
Class V-like SAM-binding methyltransferase superfamily
Target Tissue Specificity
Expressed in brain, heart, skeletal muscle, testes, prostate.
Target Research Area
Immunology
Target Synonyms
PFM5; PR domain containing 8; PR domain containing protein 8; PR domain protein 8; PR domain zinc finger protein 8; PR domain-containing protein 8; PRDM8; PRDM8_HUMAN
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