Recombinant Human CCR4-NOT transcription complex subunit 6-like (CNOT6L)

Uniprot Id

Q96LI5

Target Species

Human

Target Name

CNOT6L

Target Full Name

CCR4-NOT transcription complex subunit 6-like

Target Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

CCR4/nocturin family

Target Tissue Specificity

Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

CNOT6L; CCR4BCCR4-NOT transcription complex subunit 6-like; EC 3.1.13.4; Carbon catabolite repressor protein 4 homolog B