Recombinant Human Integrin-linked protein kinase (ILK)

Cat.No	ACP01116	Target Name	ILK
Target Synonyms	(59 kDa serine/threonine-protein kinase)(Beta-integrin-linked kinase)(ILK-1)(ILK-2)(p59ILK)	Form	Liquid or Lyophilized powder
Expression System	Baculovirus	Expression Range	1-452aa
Mol Weight	54.8 kDa	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01116

Target Name

ILK

Target Synonyms

(59 kDa serine/threonine-protein kinase)(Beta-integrin-linked kinase)(ILK-1)(ILK-2)(p59ILK)

Form

Liquid or Lyophilized powder

Expression System

Baculovirus

Expression Range

1-452aa

Mol Weight

54.8 kDa

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q13418

Background Information

Uniprot Id

Q13418
Target Species

Human
Target Name

ILK
Target Full Name

Scaffold protein ILK
Target Function

Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Target Subcellular Location

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere.
Target Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family
Target Tissue Specificity

Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Target Research Area

Signal Transduction
Target Synonyms

59 kDa serine/threonine protein kinase; 59 kDa serine/threonine-protein kinase; DKFZp686F1765 ; Epididymis secretory protein Li 28; HEL S 28; ILK 1; ILK 2; ILK; ILK-1; ILK-2; ILK_HUMAN; ILK1; ILK2; Integrin linked kinase 2; Integrin linked Kinase; Integrin linked protein kinase; Integrin-linked protein kinase; p59; p59ILK
Target Background

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants.

Recombinant Human Integrin-linked protein kinase (ILK)

Specifications

Immunogen Information

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