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The expression of recombinant Human RNASE7 protein involves transfecting e.coli cells with a DNA expression vector carrying the gene for the protein of interest (29-156aa). After transfection, the cells are cultured to produce the desired protein. A N-terminal 6xHis tag is fused to the protein. The recombinant Human RNASE7 protein is collected and purified from the cell lysate through affinity purification, attaining a purity greater than 85%, as determined by SDS-PAGE.
The expression of recombinant Human RNASE7 protein involves transfecting e.coli cells with a DNA expression vector carrying the gene for the protein of interest (29-156aa). After transfection, the cells are cultured to produce the desired protein. A N-terminal 6xHis tag is fused to the protein. The recombinant Human RNASE7 protein is collected and purified from the cell lysate through affinity purification, attaining a purity greater than 85%, as determined by SDS-PAGE.
| Cat.No | ACP01226 | Target Name | RNASE7 |
|---|---|---|---|
| Target Synonyms | (RNase 7)(Skin-derived antimicrobial protein 2)(SAP-2) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 29-156aa |
| Mol Weight | 18.6 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H1E1 |
|---|
Uniprot Id
Q9H1E1
Target Species
Human
Target Name
RNASE7
Target Full Name
Ribonuclease 7
Target Function
Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
Target Subcellular Location
Secreted.
Target Protein Families
Pancreatic ribonuclease family
Target Tissue Specificity
Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
EC 3.1.27.-; MGC133220; Ribonuclease 7; ribonuclease, RNase A family, 7; RNAS7_HUMAN; RNase 7; RNASE7; SAP 2; SAP-2; Skin derived antimicrobial protein 2; Skin-derived antimicrobial protein 2
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