Recombinant Human Short transient receptor potential channel 6 (TRPC6), Truncated

Uniprot Id

Q9Y210

Target Species

Human

Target Name

TRPC6

Target Full Name

Short transient receptor potential channel 6

Target Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

Target Involvement

Focal segmental glomerulosclerosis 2 (FSGS2)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC6 sub-subfamily

Target Tissue Specificity

Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.

Target Research Area

Neuroscience

Target Synonyms

TRP6; FSGS2; TRPC6

Target Background

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).