Recombinant Human E3 ubiquitin-protein ligase HUWE1 (HUWE1), Truncated

Cat.No	ACP01503	Target Name	HUWE1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	4005-4374aa	Mol Weight	50.7 kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01503

Target Name

HUWE1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

4005-4374aa

Mol Weight

50.7 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q7Z6Z7

Background Information

Uniprot Id

Q7Z6Z7
Target Species

Human
Target Name

HUWE1
Target Full Name

E3 ubiquitin-protein ligase HUWE1
Target Function

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC. Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1. Binds to an upstream initiator-like sequence in the preprodynorphin gene
Target Involvement

Mental retardation, X-linked, syndromic, Turner type (MRXST); Mental retardation, X-linked 17 (MRX17)
Target Subcellular Location

Cytoplasm. Nucleus. Mitochondrion.
Target Protein Families

UPL family, TOM1/PTR1 subfamily
Target Tissue Specificity

Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas.
Target Research Area

Cell Biology
Target Synonyms

ARF binding protein 1; ARF BP1; ARF-binding protein 1; ARF-BP1; ARFBP1; BJ-HCC-24 tumor antigen; E3 ubiquitin protein ligase HUWE1; E3 ubiquitin-protein ligase HUWE1; HECT; HECT domain protein LASU1; HECT UBA and WWE domain containing protein 1; HectH9; Homologous to E6AP carboxyl terminus homologous protein 9; Huwe1; HUWE1_HUMAN; Ib772; Large structure of UREB1; LASU1; Mcl 1 ubiquitin ligase E3; Mcl-1 ubiquitin ligase E3; Mule; UBA and WWE domain-containing protein 1; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1; UREB1

Recombinant Human E3 ubiquitin-protein ligase HUWE1 (HUWE1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human E3 ubiquitin-protein ligase HUWE1 (HUWE1), Truncated Now

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