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Amino acids 1-541 form the expressed segment for recombinant Human FTCD. This FTCD protein is expected to have a theoretical molecular weight of 60 kDa. This protein is generated in a yeast-based system. The FTCD gene fragment has been modified by fusing the C-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant FTCD protein during the following stages.Human Formimidoyltransferase-Cyclodeaminase (FTCD) is a bifunctional enzyme involved in the histidine catabolic pathway. It consists of two domains: the formiminotransferase domain and the cyclodeaminase domain. In the formiminotransferase reaction, FTCD catalyzes the transfer of the formimino group from N-formimino-L-glutamate to tetrahydrofolate, producing formate and 5,10-methenyltetrahydrofolate. In the cyclodeaminase reaction, FTCD converts formiminoglutamate to formamide and ammonia. This enzyme plays a crucial role in maintaining histidine homeostasis and folate metabolism. Research on FTCD includes exploring its role in disorders related to histidine metabolism, understanding its impact on folate utilization, and investigating its potential implications in human health and diseases.
Amino acids 1-541 form the expressed segment for recombinant Human FTCD. This FTCD protein is expected to have a theoretical molecular weight of 60 kDa. This protein is generated in a yeast-based system. The FTCD gene fragment has been modified by fusing the C-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant FTCD protein during the following stages.Human Formimidoyltransferase-Cyclodeaminase (FTCD) is a bifunctional enzyme involved in the histidine catabolic pathway. It consists of two domains: the formiminotransferase domain and the cyclodeaminase domain. In the formiminotransferase reaction, FTCD catalyzes the transfer of the formimino group from N-formimino-L-glutamate to tetrahydrofolate, producing formate and 5,10-methenyltetrahydrofolate. In the cyclodeaminase reaction, FTCD converts formiminoglutamate to formamide and ammonia. This enzyme plays a crucial role in maintaining histidine homeostasis and folate metabolism. Research on FTCD includes exploring its role in disorders related to histidine metabolism, understanding its impact on folate utilization, and investigating its potential implications in human health and diseases.
| Cat.No | ACP01510 | Target Name | FTCD |
|---|---|---|---|
| Target Synonyms | (Formiminotransferase-cyclodeaminase)(FTCD)(LCHC1) | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 1-541aa |
| Mol Weight | 60 kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95954 |
|---|
Uniprot Id
O95954
Target Species
Human
Target Name
FTCD
Target Full Name
Formimidoyltransferase-cyclodeaminase
Target Function
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.
Target Involvement
Glutamate formiminotransferase deficiency (FIGLU-URIA)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Note=More abundantly located around the mother centriole.
Target Protein Families
Cyclodeaminase/cyclohydrolase family; Formiminotransferase family
Target Research Area
Others
Target Synonyms
Formimidoyltetrahydrofolate cyclodeaminase; Formimidoyltransferase cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase cyclodeaminase; Formiminotransferase-cyclodeaminase; FTCD; FTCD_HUMAN; Glutamate formiminotransferase; Glutamate formyltransferase; LCHC 1; LCHC1
Target Background
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
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