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The recombinant Human PRDX3 protein expression involves the transfection of e.coli cells with a DNA expression vector containing the gene encoding the protein of interest (63-256aa). Following transfection, the cells are cultured to induce the expression of the desired protein. The protein is equipped with a N-terminal 6xHis tag. The recombinant Human PRDX3 protein is collected and purified from the cell lysate through affinity purification, achieving a purity greater than 90%, as determined by SDS-PAGE.
The recombinant Human PRDX3 protein expression involves the transfection of e.coli cells with a DNA expression vector containing the gene encoding the protein of interest (63-256aa). Following transfection, the cells are cultured to induce the expression of the desired protein. The protein is equipped with a N-terminal 6xHis tag. The recombinant Human PRDX3 protein is collected and purified from the cell lysate through affinity purification, achieving a purity greater than 90%, as determined by SDS-PAGE.
| Cat.No | ACP01725 | Target Name | PRDX3 |
|---|---|---|---|
| Target Synonyms | (Antioxidant protein 1)(AOP-1)(HBC189)(Peroxiredoxin III)(Prx-III)(Peroxiredoxin-3)(Protein MER5 homolog)(Thioredoxin-dependent peroxiredoxin 3) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 63-256aa |
| Mol Weight | 25.5 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P30048 |
|---|
Uniprot Id
P30048
Target Species
Human
Target Name
PRDX3
Target Full Name
Thioredoxin-dependent peroxide reductase, mitochondrial
Target Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
Target Subcellular Location
Mitochondrion. Cytoplasm. Early endosome.
Target Protein Families
Peroxiredoxin family, AhpC/Prx1 subfamily
Target Research Area
Cancer
Target Synonyms
Antioxidant protein 1; AOP 1; AOP-1; AOP1; HBC189; MER5; MGC104387; MGC24293; mitochondrial; peroxiredoxin 3; Peroxiredoxin III; Peroxiredoxin-3; PRDX3; PRDX3_HUMAN; PRO1748; Protein MER5 homolog; PRX III; Prx-III; PRX3; SP 22; SP-22; SP22; Thioredoxin dependent peroxide reductase mitochondrial; Thioredoxin-dependent peroxide reductase
Target Background
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22.
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