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Amino acids 269-357 form the expressed segment for recombinant Human GPRC5A. The theoretical molecular weight of the GPRC5A protein is 37.0 kDa. This GPRC5A protein is produced using e.coli expression system. The GPRC5A gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant GPRC5A protein during the following stages.Retinoic acid-induced protein 3 (RAI3), also known as GPRC5A, belongs to the G protein-coupled receptor (GPCR) family. GPRC5A is expressed in several tissues, including the lung, and has been implicated in processes such as cell proliferation, differentiation, and apoptosis. GPRC5A's role in cancer biology, particularly in lung cancer, is of significant interest, as it may function as a tumor suppressor or promoter depending on the context.
Amino acids 269-357 form the expressed segment for recombinant Human GPRC5A. The theoretical molecular weight of the GPRC5A protein is 37.0 kDa. This GPRC5A protein is produced using e.coli expression system. The GPRC5A gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant GPRC5A protein during the following stages.Retinoic acid-induced protein 3 (RAI3), also known as GPRC5A, belongs to the G protein-coupled receptor (GPCR) family. GPRC5A is expressed in several tissues, including the lung, and has been implicated in processes such as cell proliferation, differentiation, and apoptosis. GPRC5A’s role in cancer biology, particularly in lung cancer, is of significant interest, as it may function as a tumor suppressor or promoter depending on the context.
| Cat.No | ACP01926 | Target Name | GPRC5A |
|---|---|---|---|
| Target Synonyms | GPRC5A; GPCR5A; RAI3; RAIG1; Retinoic acid-induced protein 3; G-protein coupled receptor family C group 5 member A; Phorbol ester induced gene 1; PEIG-1; Retinoic acid-induced gene 1 protein; RAIG-1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 269-357aa |
| Mol Weight | 37.0 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NFJ5 |
|---|
Uniprot Id
Q8NFJ5
Target Species
Human
Target Name
GPRC5A
Target Full Name
Retinoic acid-induced protein 3
Target Function
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 3 family
Target Tissue Specificity
Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to mod
Target Research Area
Neuroscience
Target Synonyms
GPRC5A; GPCR5A; RAI3; RAIG1; Retinoic acid-induced protein 3; G-protein coupled receptor family C group 5 member A; Phorbol ester induced gene 1; PEIG-1; Retinoic acid-induced gene 1 protein; RAIG-1
Target Background
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.
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