Recombinant Human Neuronal acetylcholine receptor subunit beta-2 (CHRNB2), Truncated

Uniprot Id

P17787

Target Species

Human

Target Name

CHRNB2

Target Full Name

Neuronal acetylcholine receptor subunit beta-2

Target Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.

Target Involvement

Epilepsy, nocturnal frontal lobe, 3 (ENFL3)

Target Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Beta-2/CHRNB2 sub-subfamily

Target Research Area

Cancer

Target Synonyms

CHRNB2; Neuronal acetylcholine receptor subunit beta-2

Target Background

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.