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The expression region of this recombinant Human PCBD1 covers amino acids 2-104. The theoretical molecular weight of the PCBD1 protein is 15.9 kDa. This PCBD1 protein is produced using e.coli expression system. The PCBD1 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant PCBD1 protein in following stages of expression and purification.Pterin-4-alpha-carbinolamine dehydratase (PCBD1) is a crucial enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for various enzymes, including those participating in neurotransmitter synthesis and nitric oxide production. PCBD1 catalyzes the conversion of 6-pyruvoyl tetrahydropterin to dihydrobiopterin, a key step in the BH4 biosynthetic pathway. Beyond its role in BH4 synthesis, PCBD1 has been associated with various cellular functions, including the regulation of oxidative stress and the modulation of endothelial nitric oxide synthase (eNOS) activity. Additionally, PCBD1 plays a vital role in maintaining redox balance, making it crucial for proper cellular function. Research on PCBD1 focuses on understanding its molecular mechanisms, exploring its interactions with other proteins in the BH4 pathway, and investigating its implications in diseases related to BH4 deficiency or redox imbalance.
The expression region of this recombinant Human PCBD1 covers amino acids 2-104. The theoretical molecular weight of the PCBD1 protein is 15.9 kDa. This PCBD1 protein is produced using e.coli expression system. The PCBD1 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant PCBD1 protein in following stages of expression and purification.Pterin-4-alpha-carbinolamine dehydratase (PCBD1) is a crucial enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for various enzymes, including those participating in neurotransmitter synthesis and nitric oxide production. PCBD1 catalyzes the conversion of 6-pyruvoyl tetrahydropterin to dihydrobiopterin, a key step in the BH4 biosynthetic pathway. Beyond its role in BH4 synthesis, PCBD1 has been associated with various cellular functions, including the regulation of oxidative stress and the modulation of endothelial nitric oxide synthase (eNOS) activity. Additionally, PCBD1 plays a vital role in maintaining redox balance, making it crucial for proper cellular function. Research on PCBD1 focuses on understanding its molecular mechanisms, exploring its interactions with other proteins in the BH4 pathway, and investigating its implications in diseases related to BH4 deficiency or redox imbalance.
| Cat.No | ACP02004 | Target Name | PCBD1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-104aa | Mol Weight | 15.9 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P61457 |
|---|
Uniprot Id
P61457
Target Species
Human
Target Name
PCBD1
Target Full Name
Pterin-4-alpha-carbinolamine dehydratase
Target Function
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription.
Target Involvement
Hyperphenylalaninemia, BH4-deficient, D (HPABH4D)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Pterin-4-alpha-carbinolamine dehydratase family
Target Research Area
Metabolism, Epigenetics and Nuclear Signaling
Target Synonyms
4 alpha hydroxy tetrahydropterin dehydratase; 4-alpha-hydroxy-tetrahydropterin dehydratase; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; DCoH; Dimerization cofactor of hepatic nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Dimerization cofactor of HNF1; Dimerizing cofactor for HNF1; PCBD 1; PCBD; PCBD1; PCD; Phenylalanine hydroxylase stimulating protein; Phenylalanine hydroxylase-stimulating protein; PHS; PHS_HUMAN; Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Pterin carbinolamine dehydratase; Pterin-4-alpha-carbinolamine dehydratase
Target Background
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.
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