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Amino acids 1-207 constitute the expression domain of recombinant Human AANAT. This AANAT protein is theoretically predicted to have a molecular weight of 51.8 kDa. This AANAT protein is produced using e.coli expression system. Fusion of the N-terminal 10xHis-GST tag into the AANAT encoding gene fragment was conducted, allowing for easier detection and purification of the AANAT protein in subsequent stages.Human serotonin N-Acetyltransferase (AANAT) is a key enzyme in the synthesis of melatonin, the hormone that regulates circadian rhythms. AANAT catalyzes the conversion of serotonin to N-acetylserotonin, a precursor in melatonin biosynthesis. In chronobiology, AANAT is pivotal for the molecular clock, linking light-dark cycles to melatonin production. In neuroscience, AANAT influences sleep-wake cycles and mood regulation. In endocrinology, melatonin has roles in reproductive physiology and immune function. Investigating AANAT provides insights into circadian rhythm regulation, sleep disorders, and mood-related conditions, offering potential applications in chronotherapy, neuropsychiatry, and endocrine research for therapeutic interventions and understanding melatonin's broader physiological roles.
Amino acids 1-207 constitute the expression domain of recombinant Human AANAT. This AANAT protein is theoretically predicted to have a molecular weight of 51.8 kDa. This AANAT protein is produced using e.coli expression system. Fusion of the N-terminal 10xHis-GST tag into the AANAT encoding gene fragment was conducted, allowing for easier detection and purification of the AANAT protein in subsequent stages.Human serotonin N-Acetyltransferase (AANAT) is a key enzyme in the synthesis of melatonin, the hormone that regulates circadian rhythms. AANAT catalyzes the conversion of serotonin to N-acetylserotonin, a precursor in melatonin biosynthesis. In chronobiology, AANAT is pivotal for the molecular clock, linking light-dark cycles to melatonin production. In neuroscience, AANAT influences sleep-wake cycles and mood regulation. In endocrinology, melatonin has roles in reproductive physiology and immune function. Investigating AANAT provides insights into circadian rhythm regulation, sleep disorders, and mood-related conditions, offering potential applications in chronotherapy, neuropsychiatry, and endocrine research for therapeutic interventions and understanding melatonin’s broader physiological roles.
| Cat.No | ACP02377 | Target Name | AANAT |
|---|---|---|---|
| Target Synonyms | AA-NAT; Aanat; Aralkylamine N-acetyltransferase; Arylalkylamine N acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT; SNAT_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-207aa |
| Mol Weight | 51.8 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16613 |
|---|
Uniprot Id
Q16613
Target Species
Human
Target Name
AANAT
Target Full Name
Serotonin N-acetyltransferase
Target Function
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Acetyltransferase family, AANAT subfamily
Target Tissue Specificity
Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
Target Research Area
Neuroscience
Target Synonyms
AA-NAT; Aanat; Aralkylamine N-acetyltransferase; Arylalkylamine N acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT; SNAT_HUMAN
Target Background
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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