Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), Truncated

Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1) is a partial length protein expressed with an N-terminal 6xHis-tagged in the E.coli. Its expression region corresponds to 21-255aa (Extracellular Domain) of human CHRNA1 protein. It underwent validation via the LC-MS/MS analysis. Its purity reached up to 90% determined by SDS-PAGE. Under reducing conditions, a molecular weight band of around 32 kDa was visualized on the gel. This recombinant CHRNA1 protein is in stock now. CHRNA1 is a component of acetylcholine receptors (AChRs) that are neurotransmitter receptors in the neuronal system. This protein plays a role in acetlycholine binding/channel gating. The ACh/AChR signaling is essential to normal the central nervous system (CNS) function. Alterations in this signaling lead to multiple neuropsychiatric disorders, including Myasthenic Syndrome, Congenital, 1B, Fast-Channel and Myasthenic Syndrome, Congenital, 1A, Slow-Channel.

ACP02518

Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1) is a partial length protein expressed with an N-terminal 6xHis-tagged in the E.coli. Its expression region corresponds to 21-255aa (Extracellular Domain) of human CHRNA1 protein. It underwent validation via the LC-MS/MS analysis. Its purity reached up to 90% determined by SDS-PAGE. Under reducing conditions, a molecular weight band of around 32 kDa was visualized on the gel. This recombinant CHRNA1 protein is in stock now.
CHRNA1 is a component of acetylcholine receptors (AChRs) that are neurotransmitter receptors in the neuronal system. This protein plays a role in acetlycholine binding/channel gating. The ACh/AChR signaling is essential to normal the central nervous system (CNS) function. Alterations in this signaling lead to multiple neuropsychiatric disorders, including Myasthenic Syndrome, Congenital, 1B, Fast-Channel and Myasthenic Syndrome, Congenital, 1A, Slow-Channel.

Number

Cat.No	ACP02518	Target Name	CHRNA1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	21-255aa	Mol Weight	31.1kDa
Protein Length	Partial of P02708-1	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02518

Target Name

CHRNA1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

21-255aa

Mol Weight

31.1kDa

Protein Length

Partial of P02708-1

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P02708

Background Information

Uniprot Id

P02708
Target Species

Human
Target Name

CHRNA1
Target Full Name

Acetylcholine receptor subunit alpha
Target Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Target Involvement

Multiple pterygium syndrome, lethal type (LMPS); Myasthenic syndrome, congenital, 1A, slow-channel (CMS1A); Myasthenic syndrome, congenital, 1B, fast-channel (CMS1B)
Target Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-1/CHRNA1 sub-subfamily
Target Tissue Specificity

Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
Target Research Area

Neuroscience, Transport
Target Synonyms

Acetylcholine receptor subunit alpha; ACHA_HUMAN; AChR; ACHRA; ACHRD; CHNRA; Cholinergic receptor nicotinic alpha 1 subunit; Cholinergic receptor nicotinic alpha polypeptide 1; Cholinergic receptor; nicotinic; alpha polypeptide 1 (muscle); Chrna1; CMS1A; CMS1B; CMS2A; FCCMS; Nicotinic cholinergic receptor alpha 1; SCCMS; Schizophrenia neurophysiologic defect candidate
Target Background

The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.

Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), Truncated

Specifications

Immunogen Information

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