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The region for expressing recombinant Human SYN1 contains amino acids 113-420. This SYN1 protein is expected to have a theoretical molecular weight of 61.6 kDa. This SYN1 protein is produced using e.coli expression system. The SYN1 coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant SYN1 protein in following stages of expression and purification.Synapsin-1 (SYN1) is a neuronal phosphoprotein that plays a crucial role in regulating neurotransmitter release and synaptic vesicle trafficking. It belongs to the synapsin family, which consists of three isoforms (I, II, and III) and is primarily associated with the presynaptic terminals of neurons. SYN1 is involved in the modulation of synaptic transmission by tethering synaptic vesicles to the cytoskeleton and regulating their availability for release. Phosphorylation of SYN1 by various protein kinases, including cAMP-dependent protein kinase (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII), is a key regulatory mechanism controlling its activity. Research on SYN1 encompasses investigations into synaptic plasticity, neurotransmitter release, and the molecular mechanisms underlying neurological and psychiatric disorders, as alterations in SYN1 function have been implicated in conditions such as epilepsy, schizophrenia, and bipolar disorder.
The region for expressing recombinant Human SYN1 contains amino acids 113-420. This SYN1 protein is expected to have a theoretical molecular weight of 61.6 kDa. This SYN1 protein is produced using e.coli expression system. The SYN1 coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant SYN1 protein in following stages of expression and purification.Synapsin-1 (SYN1) is a neuronal phosphoprotein that plays a crucial role in regulating neurotransmitter release and synaptic vesicle trafficking. It belongs to the synapsin family, which consists of three isoforms (I, II, and III) and is primarily associated with the presynaptic terminals of neurons. SYN1 is involved in the modulation of synaptic transmission by tethering synaptic vesicles to the cytoskeleton and regulating their availability for release. Phosphorylation of SYN1 by various protein kinases, including cAMP-dependent protein kinase (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII), is a key regulatory mechanism controlling its activity. Research on SYN1 encompasses investigations into synaptic plasticity, neurotransmitter release, and the molecular mechanisms underlying neurological and psychiatric disorders, as alterations in SYN1 function have been implicated in conditions such as epilepsy, schizophrenia, and bipolar disorder.
| Cat.No | ACP02582 | Target Name | SYN1 |
|---|---|---|---|
| Target Synonyms | Brain protein 4.1; SYN 1; SYN 1a; SYN 1b; SYN I; SYN1; SYN1_HUMAN; SYN1a; SYN1b; Synapsin 1; Synapsin I; Synapsin-1; Synapsin1; SynapsinI; SYNI | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 113-420aa |
| Mol Weight | 61.6kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P17600 |
|---|
Uniprot Id
P17600
Target Species
Human
Target Name
SYN1
Target Full Name
Synapsin-1
Target Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Target Involvement
Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD)
Target Subcellular Location
Cell junction, synapse. Golgi apparatus.
Target Protein Families
Synapsin family
Target Research Area
Neuroscience
Target Synonyms
Brain protein 4.1; SYN 1; SYN 1a; SYN 1b; SYN I; SYN1; SYN1_HUMAN; SYN1a; SYN1b; Synapsin 1; Synapsin I; Synapsin-1; Synapsin1; SynapsinI; SYNI
Target Background
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
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