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Recombinant Human Cold-inducible RNA-binding protein (CIRBP)

ACP02687

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Specifications

Cat.No	ACP02687	Target Name	CIRBP
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-172aa	Mol Weight	45.6kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q14011

Background Information

Uniprot Id

Q14011
Target Species

Human
Target Name

CIRBP
Target Full Name

Cold-inducible RNA-binding protein
Target Function

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
Target Subcellular Location

Nucleus, nucleoplasm. Cytoplasm.
Target Tissue Specificity

Ubiquitous.
Target Research Area

Cell Biology, Epigenetics and Nuclear Signaling
Target Synonyms

A18 hnRNP; A18HNRNP; cirbp; CIRBP_HUMAN; CIRP; Cold inducible RNA binding protein; Cold-inducible RNA-binding protein; Glycine rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39
Target Background

Enables mRNA 3'-UTR binding activity and small ribosomal subunit rRNA binding activity. Involved in mRNA stabilization; positive regulation of translation; and response to UV. Located in cytoplasm and nucleoplasm.

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Recombinant Human Cold-inducible RNA-binding protein (CIRBP)

Specifications

Immunogen Information

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