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Amino acids 5-451 form the expressed segment for recombinant Human SEPSECS. The expected molecular weight for the SEPSECS protein is calculated to be 53.4 kDa. This SEPSECS recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of SEPSECS, making it easier to detect and purify the SEPSECS recombinant protein in the later stages of expression and purification.The human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) is an essential enzyme involved in the biosynthesis of selenocysteine (Sec), a rare amino acid that contains selenium. SEPSECS plays a crucial role in the unique mechanism by which selenocysteine is incorporated into proteins during translation. SEPSECS catalyzes the conversion of O-phosphoseryl-tRNA (Sec) to selenocysteinyl-tRNA (Sec), a key step in the synthesis of selenoproteins. Selenoproteins are involved in various biological processes, including antioxidant defense and redox regulation. Research on SEPSECS focuses on understanding its role in selenocysteine biosynthesis, the regulation of selenoprotein expression, and the impact of selenoproteins on cellular functions.
Amino acids 5-451 form the expressed segment for recombinant Human SEPSECS. The expected molecular weight for the SEPSECS protein is calculated to be 53.4 kDa. This SEPSECS recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of SEPSECS, making it easier to detect and purify the SEPSECS recombinant protein in the later stages of expression and purification.The human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) is an essential enzyme involved in the biosynthesis of selenocysteine (Sec), a rare amino acid that contains selenium. SEPSECS plays a crucial role in the unique mechanism by which selenocysteine is incorporated into proteins during translation. SEPSECS catalyzes the conversion of O-phosphoseryl-tRNA (Sec) to selenocysteinyl-tRNA (Sec), a key step in the synthesis of selenoproteins. Selenoproteins are involved in various biological processes, including antioxidant defense and redox regulation. Research on SEPSECS focuses on understanding its role in selenocysteine biosynthesis, the regulation of selenoprotein expression, and the impact of selenoproteins on cellular functions.
| Cat.No | ACP02828 | Target Name | SEPSECS |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 5-451aa | Mol Weight | 53.4kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HD40 |
|---|
Uniprot Id
Q9HD40
Target Species
Human
Target Name
SEPSECS
Target Full Name
O-phosphoseryl-tRNA(Sec) selenium transferase
Target Function
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Target Involvement
Pontocerebellar hypoplasia 2D (PCH2D)
Target Subcellular Location
Cytoplasm.
Target Protein Families
SepSecS family
Target Tissue Specificity
Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
Target Research Area
Epigenetics and Nuclear Signaling, Metabolism
Target Synonyms
DKFZp434B1417; Liver pancreas antigen; Liver-pancreas antigen; LP; MGC161491; O phosphoseryl tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; Sec synthase; Selenocysteine synthase; Selenocysteinyl tRNA(Sec) synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase; Sep tRNA:Sec tRNA synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; SLA; SLA p35; SLA-p35; SLA/LP; SLA/LP autoantigen; Soluble liver antigen; Soluble liver antigen/liver pancreas antigen; Soluble Liver/Pancreas Antigen; SPCS_HUMAN; tRNA(Ser/Sec) associated antigenic protein; tRNA(Ser/Sec)-associated antigenic protein; TRNP48; UGA suppressor tRNA associated protein; UGA suppressor tRNA-associated protein
Target Background
The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).
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