Recombinant Human Gasdermin-C (GSDMC)

Cat.No	ACP03170	Target Name	GSDMC
Target Synonyms	extra nuclear factor; Melanoma-derived leucine zipper-containing extranuclear factor; MLZE, Gasdermin C; Gasdermin-C; GSDMC; GSDMC_HUMAN; Melanoma derived leucine zipper	Form	Liquid or Lyophilized powder
Expression System	Baculovirus	Expression Range	1-508aa
Mol Weight	61.7 kDa	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03170

Target Name

GSDMC

Target Synonyms

extra nuclear factor; Melanoma-derived leucine zipper-containing extranuclear factor; MLZE, Gasdermin C; Gasdermin-C; GSDMC; GSDMC_HUMAN; Melanoma derived leucine zipper

Form

Liquid or Lyophilized powder

Expression System

Baculovirus

Expression Range

1-508aa

Mol Weight

61.7 kDa

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9BYG8

Background Information

Uniprot Id

Q9BYG8
Target Species

Human
Target Name

GSDMC
Target Full Name

Gasdermin-C
Target Function

This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.; Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable).
Target Subcellular Location

[Gasdermin-C]: Cytoplasm, cytosol.; [Gasdermin-C, N-terminal]: Cell membrane; Multi-pass membrane protein.
Target Protein Families

Gasdermin family
Target Tissue Specificity

Expressed mainly in trachea and spleen. In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium.
Target Research Area

Cancer
Target Synonyms

Gasdermin C; Gasdermin-C; GSDMC; GSDMC_HUMAN; Melanoma derived leucine zipper, extra nuclear factor; Melanoma-derived leucine zipper-containing extranuclear factor; MLZE
Target Background

Predicted to enable phosphatidylinositol-4, 5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within intestinal epithelial cell development. Located in cytoplasm.

Recombinant Human Gasdermin-C (GSDMC)

Specifications

Immunogen Information

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