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Recombinant Human Trichoplein keratin filament-binding protein (TCHP)

ACP03191

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Specifications

Cat.No	ACP03191	Target Name	TCHP
Target Synonyms	TCHP; Trichoplein keratin filament-binding protein; Protein TCHP; Mitochondrial protein with oncostatic activity; Mitostatin; Tumor suppressor protein	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-498aa
Mol Weight	77.1kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9BT92

Background Information

Uniprot Id

Q9BT92
Target Species

Human
Target Name

TCHP
Target Full Name

Trichoplein keratin filament-binding protein
Target Function

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis.
Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion. Cell junction, desmosome.
Target Protein Families

TCHP family
Target Tissue Specificity

Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest le
Target Research Area

Cancer
Target Synonyms

TCHP; Trichoplein keratin filament-binding protein; Protein TCHP; Mitochondrial protein with oncostatic activity; Mitostatin; Tumor suppressor protein

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Recombinant Human Trichoplein keratin filament-binding protein (TCHP)

Specifications

Immunogen Information

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