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| Cat.No | ACP03378 | Target Name | MFF |
|---|---|---|---|
| Target Synonyms | C2orf33 ; Chromosome 2 open reading frame 33; DKFZp666J168; GL004 ; Mff; MFF_HUMAN; MGC110913; Mitochondrial fission factor; OTTHUMP00000164235 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-322aa |
| Mol Weight | 39.9 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9GZY8 |
|---|
Uniprot Id
Q9GZY8
Target Species
Human
Target Name
MFF
Target Full Name
Mitochondrial fission factor
Target Function
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Target Involvement
Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2)
Target Subcellular Location
Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
Target Protein Families
Tango11 family
Target Tissue Specificity
Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
Target Research Area
Others
Target Synonyms
C2orf33 ; Chromosome 2 open reading frame 33; DKFZp666J168; GL004 ; Mff; MFF_HUMAN; MGC110913; Mitochondrial fission factor; OTTHUMP00000164235
Target Background
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
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