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The region for expressing recombinant Human HMGN2 contains amino acids 1-90. The theoretical molecular weight of the HMGN2 protein is 36.4 kDa. The HMGN2 protein was expressed in e.coli. The HMGN2 gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant HMGN2 protein during the following stages.The human non-histone chromosomal protein HMG-17, encoded by the HMGN2 gene, is involved in chromatin structure regulation and plays a role in transcriptional regulation. HMG-17 binds to nucleosomes and alters the structure of chromatin, affecting the accessibility of transcription factors to DNA. HMG-17 is known to influence gene expression, participating in both activation and repression of transcription. Additionally, it has been implicated in various cellular processes, including DNA repair and maintenance of genomic stability. Research on HMGN2 spans multiple areas, such as understanding its precise mechanisms in chromatin dynamics, its impact on gene regulation, and its potential implications in diseases like cancer. Investigations into HMGN2 contribute to unraveling the complex network of chromatin-associated proteins and their roles in cellular function.
The region for expressing recombinant Human HMGN2 contains amino acids 1-90. The theoretical molecular weight of the HMGN2 protein is 36.4 kDa. The HMGN2 protein was expressed in e.coli. The HMGN2 gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant HMGN2 protein during the following stages.The human non-histone chromosomal protein HMG-17, encoded by the HMGN2 gene, is involved in chromatin structure regulation and plays a role in transcriptional regulation. HMG-17 binds to nucleosomes and alters the structure of chromatin, affecting the accessibility of transcription factors to DNA. HMG-17 is known to influence gene expression, participating in both activation and repression of transcription. Additionally, it has been implicated in various cellular processes, including DNA repair and maintenance of genomic stability. Research on HMGN2 spans multiple areas, such as understanding its precise mechanisms in chromatin dynamics, its impact on gene regulation, and its potential implications in diseases like cancer. Investigations into HMGN2 contribute to unraveling the complex network of chromatin-associated proteins and their roles in cellular function.
| Cat.No | ACP03519 | Target Name | HMGN2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-90aa | Mol Weight | 36.4 kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05204 |
|---|
Uniprot Id
P05204
Target Species
Human
Target Name
HMGN2
Target Full Name
Non-histone chromosomal protein HMG-17
Target Function
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
Target Subcellular Location
Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.
Target Protein Families
HMGN family
Target Research Area
others
Target Synonyms
High mobility group (nonhistone chromosomal) protein 17 ; high mobility group nucleosomal binding domain 2; High mobility group nucleosome-binding domain-containing protein 2; High mobility group protein N2 ; HMG17; HMGN2; HMGN2_HUMAN; MGC5629; Non histone chromosomal protein HMG 17; Non-histone chromosomal protein HMG-17; Nonhistone chromosomal protein HMG 17; nonhistone chromosomal protein hmg-17
Target Background
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi.
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