Recombinant Human Ras-related protein Rab-10 (RAB10), Truncated

The expression region of this recombinant Human RAB10 covers amino acids 1-196. This RAB10 protein is expected to have a theoretical molecular weight of 26.1 kDa. This protein is generated in a e.coli-based system. The RAB10 coding gene included the N-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant RAB10 protein in following stages of expression and purification.Ras-related protein Rab-10 (RAB10) is a member of the Rab GTPase family, which plays a crucial role in regulating intracellular membrane trafficking and vesicle transport. RAB10 specifically participates in the control of various cellular processes, including endocytosis, exocytosis, and organelle organization. It is primarily associated with the regulation of protein trafficking between the trans-Golgi network and recycling endosomes. The main function of RAB10 involves the coordination of vesicle transport and membrane fusion, contributing to the maintenance of cellular architecture and organelle dynamics. Research areas related to RAB10 often focus on understanding its role in cellular processes, including its involvement in the regulation of insulin-stimulated glucose transporter (GLUT4) trafficking, which has implications for metabolic disorders such as diabetes.

ACP03547

Number

Cat.No	ACP03547	Target Name	RAB10
Target Synonyms	GTP binding protein RAB10; Rab10; RAB10 member RAS oncogene family; RAB10_HUMAN; Ras related GTP binding protein; Ras related GTP binding protein RAB10; Ras-related protein Rab-10	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-196aa
Mol Weight	26.1kDa	Protein Length	Partial
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03547

Target Name

RAB10

Target Synonyms

GTP binding protein RAB10; Rab10; RAB10 member RAS oncogene family; RAB10_HUMAN; Ras related GTP binding protein; Ras related GTP binding protein RAB10; Ras-related protein Rab-10

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-196aa

Mol Weight

26.1kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P61026

Background Information

Uniprot Id

P61026
Target Species

Human
Target Name

RAB10
Target Full Name

Ras-related protein Rab-10
Target Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane. In epithelial cells, it regulates transport from the Golgi to the basolateral membrane. May play a role in the basolateral recycling pathway and in phagosome maturation. May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis. When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis.; (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.
Target Subcellular Location

Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasm, cytoskeleton, cilium basal body. Endoplasmic reticulum membrane. Cytoplasm, perinuclear region.
Target Protein Families

Small GTPase superfamily, Rab family
Target Tissue Specificity

Expressed in the hippocampus. Expressed in neutrophils (at protein level).
Target Research Area

Signal Transduction
Target Synonyms

GTP binding protein RAB10; Rab10; RAB10 member RAS oncogene family; RAB10_HUMAN; Ras related GTP binding protein; Ras related GTP binding protein RAB10; Ras-related protein Rab-10
Target Background

RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).

Recombinant Human Ras-related protein Rab-10 (RAB10), Truncated

Specifications

Immunogen Information

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