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This Human MPI recombinant protein was produced in E.coli, where the gene sequence encoding Human MPI (1-423aa) was expressed with the N-terminal GST tag. The purity of this MPI protein was greater than 90% by SDS-PAGE.MPI is an important enzyme involved in various sugar metabolism pathways, including ribose and N-glycosylation. It plays a crucial role in maintaining cellular energy balance and protein modification. Defects in MPI are associated with disorders related to mannose metabolism, and it also has significant applications in biotechnology. Research on MPI contributes to a deeper understanding of sugar metabolism processes and provides insights into the treatment of related diseases.
This Human MPI recombinant protein was produced in E.coli, where the gene sequence encoding Human MPI (1-423aa) was expressed with the N-terminal GST tag. The purity of this MPI protein was greater than 90% by SDS-PAGE.MPI is an important enzyme involved in various sugar metabolism pathways, including ribose and N-glycosylation. It plays a crucial role in maintaining cellular energy balance and protein modification. Defects in MPI are associated with disorders related to mannose metabolism, and it also has significant applications in biotechnology. Research on MPI contributes to a deeper understanding of sugar metabolism processes and provides insights into the treatment of related diseases.
| Cat.No | ACP03622 | Target Name | MPI |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-423aa | Mol Weight | 73.5kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P34949 |
|---|
Uniprot Id
P34949
Target Species
Human
Target Name
MPI
Target Full Name
Mannose-6-phosphate isomerase
Target Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Target Involvement
Congenital disorder of glycosylation 1B (CDG1B)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Mannose-6-phosphate isomerase type 1 family
Target Tissue Specificity
Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.
Target Research Area
Signal Transduction
Target Synonyms
MI1; CDG1B; FLJ39201; Mannose 6 phosphate isomerase; Mannose-6-phosphate isomerase; MANNOSEPHOSPHATE ISOMERASE; MGC94106; MPI; MPI_HUMAN; Phosphohexomutase; phosphomannose isomerase 1; Phosphomannose isomerase; PMI
Target Background
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants.
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