Recombinant Human Lymphocyte activation gene 3 protein (LAG3), Truncated

Enhance your immunology research with our premium-quality Recombinant Human LAG3 protein. Lymphocyte activation gene 3 protein (LAG3, also known as CD223) plays a crucial role in regulating the immune response, notably in T cell activation and homeostasis. Investigating LAG3 function is paramount for advancing our understanding of autoimmune diseases, tumor immunology, and therapeutic immune checkpoint modulation. Our Recombinant Human LAG3 protein has been skillfully expressed in E. coli to ensure a consistent and reliable production system. Covering the extracellular domain (29-450 amino acids) of LAG3, this recombinant protein has been meticulously designed to maintain the structural and functional integrity of the native molecule. An N-terminal 6xHis-GST-tag enables efficient purification while preserving the protein's bioactivity. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human LAG3 protein is the ideal choice for your immunology research needs. Opt for our superior protein product to achieve precise and accurate insights into the role of LAG3 in immune regulation and function.

ACP03633

Enhance your immunology research with our premium-quality Recombinant Human LAG3 protein. Lymphocyte activation gene 3 protein (LAG3, also known as CD223) plays a crucial role in regulating the immune response, notably in T cell activation and homeostasis. Investigating LAG3 function is paramount for advancing our understanding of autoimmune diseases, tumor immunology, and therapeutic immune checkpoint modulation.
Our Recombinant Human LAG3 protein has been skillfully expressed in E. coli to ensure a consistent and reliable production system. Covering the extracellular domain (29-450 amino acids) of LAG3, this recombinant protein has been meticulously designed to maintain the structural and functional integrity of the native molecule. An N-terminal 6xHis-GST-tag enables efficient purification while preserving the protein’s bioactivity. With a purity of greater than 90% as determined by SDS-PAGE, our Recombinant Human LAG3 protein is the ideal choice for your immunology research needs. Opt for our superior protein product to achieve precise and accurate insights into the role of LAG3 in immune regulation and function.

Number

Cat.No	ACP03633	Target Name	LAG3
Target Synonyms	CD223; CD223 antigen; FDC protein; LAG-3; Lag3; LAG3_HUMAN; Lymphocyte activating 3; Lymphocyte activation gene 3; Lymphocyte activation gene 3 protein; Protein FDC	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	29-450aa
Mol Weight	75.6kDa	Protein Length	Extracellular Domain
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03633

Target Name

LAG3

Target Synonyms

CD223; CD223 antigen; FDC protein; LAG-3; Lag3; LAG3_HUMAN; Lymphocyte activating 3; Lymphocyte activation gene 3; Lymphocyte activation gene 3 protein; Protein FDC

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

29-450aa

Mol Weight

75.6kDa

Protein Length

Extracellular Domain

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P18627

Background Information

Uniprot Id

P18627
Target Species

Human
Target Name

LAG3
Target Full Name

Lymphocyte activation gene 3 protein
Target Function

Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear.; May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
Target Subcellular Location

[Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein.; [Secreted lymphocyte activation gene 3 protein]: Secreted.
Target Tissue Specificity

Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
Target Research Area

Immunology
Target Synonyms

CD223; CD223 antigen; FDC protein; LAG-3; Lag3; LAG3_HUMAN; Lymphocyte activating 3; Lymphocyte activation gene 3; Lymphocyte activation gene 3 protein; Protein FDC
Target Background

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Recombinant Human Lymphocyte activation gene 3 protein (LAG3), Truncated

Specifications

Immunogen Information

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