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The recombinant Human RRM1 was expressed with the amino acid range of 1-792. This RRM1 protein is expected to have a theoretical molecular weight of 92.1 kDa. The RRM1 protein was expressed in yeast. The RRM1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant RRM1 protein during the following stages.The human ribonucleoside-diphosphate reductase large subunit (RRM1) is a key component of the ribonucleotide reductase enzyme complex. RRM1 plays a crucial role in DNA synthesis by catalyzing the conversion of ribonucleotides to deoxyribonucleotides, essential building blocks for DNA replication and repair. RRM1, along with the small subunit RRM2, contributes to the reduction of ribonucleotides to deoxyribonucleotides, a critical step in DNA synthesis. The activity of ribonucleotide reductase is tightly regulated to ensure proper control of DNA synthesis during the cell cycle. Altered expression of RRM1 has been observed in various cancers. Its overexpression is associated with resistance to certain chemotherapeutic agents, making it a potential target for cancer therapy. Research on RRM1 focuses on understanding its role in DNA metabolism, cell cycle regulation, and its implications in cancer development and treatment.
The recombinant Human RRM1 was expressed with the amino acid range of 1-792. This RRM1 protein is expected to have a theoretical molecular weight of 92.1 kDa. The RRM1 protein was expressed in yeast. The RRM1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant RRM1 protein during the following stages.The human ribonucleoside-diphosphate reductase large subunit (RRM1) is a key component of the ribonucleotide reductase enzyme complex. RRM1 plays a crucial role in DNA synthesis by catalyzing the conversion of ribonucleotides to deoxyribonucleotides, essential building blocks for DNA replication and repair. RRM1, along with the small subunit RRM2, contributes to the reduction of ribonucleotides to deoxyribonucleotides, a critical step in DNA synthesis. The activity of ribonucleotide reductase is tightly regulated to ensure proper control of DNA synthesis during the cell cycle. Altered expression of RRM1 has been observed in various cancers. Its overexpression is associated with resistance to certain chemotherapeutic agents, making it a potential target for cancer therapy. Research on RRM1 focuses on understanding its role in DNA metabolism, cell cycle regulation, and its implications in cancer development and treatment.
| Cat.No | ACP03896 | Target Name | RRM1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 1-792aa | Mol Weight | 92.1kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P23921 |
|---|
Uniprot Id
P23921
Target Species
Human
Target Name
RRM1
Target Full Name
Ribonucleoside-diphosphate reductase large subunit
Target Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Ribonucleoside diphosphate reductase large chain family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
R1; Ribonucleoside diphosphate reductase large subunit; Ribonucleoside diphosphate reductase M1 chain; Ribonucleoside diphosphate reductase subunit M1; Ribonucleoside reductase; large subunit; Ribonucleoside-diphosphate reductase large subunit; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1; Ribonucleotide reductase M1 polypeptide; Ribonucleotide reductase R1 subunit ; Ribonucleotide reductase; M1 subunit; RIR 1; RIR1; RIR1_HUMAN; RR 1; RR1; RRM 1; RRM1
Target Background
This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.
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