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Amino acids 23-254 constitute the expression domain of recombinant Human SDC1. This SDC1 protein is expected to have a theoretical molecular weight of 39.9 kDa. Expression of this SDC1 protein is conducted in e.coli. The SDC1 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant SDC1 protein in following stages of expression and purification.Syndecan-1 (SDC1) is a cell surface proteoglycan that plays a crucial role in cell-matrix interactions, cell adhesion, and signaling. As a member of the syndecan family, SDC1 is involved in various physiological processes, including development, wound healing, and immune response. It acts as a coreceptor for growth factors and cytokines, mediating their signaling pathways. SDC1 also participates in cell adhesion by binding to extracellular matrix components. In cancer, SDC1 is often dysregulated and implicated in tumor progression, angiogenesis, and metastasis. Research on SDC1 spans multiple areas, including cancer biology, immunology, and developmental biology, aiming to understand its complex functions and potential therapeutic implications in various diseases.
Amino acids 23-254 constitute the expression domain of recombinant Human SDC1. This SDC1 protein is expected to have a theoretical molecular weight of 39.9 kDa. Expression of this SDC1 protein is conducted in e.coli. The SDC1 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant SDC1 protein in following stages of expression and purification.Syndecan-1 (SDC1) is a cell surface proteoglycan that plays a crucial role in cell-matrix interactions, cell adhesion, and signaling. As a member of the syndecan family, SDC1 is involved in various physiological processes, including development, wound healing, and immune response. It acts as a coreceptor for growth factors and cytokines, mediating their signaling pathways. SDC1 also participates in cell adhesion by binding to extracellular matrix components. In cancer, SDC1 is often dysregulated and implicated in tumor progression, angiogenesis, and metastasis. Research on SDC1 spans multiple areas, including cancer biology, immunology, and developmental biology, aiming to understand its complex functions and potential therapeutic implications in various diseases.
| Cat.No | ACP04012 | Target Name | SDC1 |
|---|---|---|---|
| Target Synonyms | CD_antigen; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; Sdc1; SDC1_HUMAN; SYND1; Syndecan 1; Syndecan; syndecan proteoglycan 1; Syndecan-1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 23-254aa |
| Mol Weight | 39.9kDa | Protein Length | Extracellular Domain |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P18827 |
|---|
Uniprot Id
P18827
Target Species
Human
Target Name
SDC1
Target Full Name
Syndecan-1
Target Function
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Target Subcellular Location
Membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular exosome.
Target Protein Families
Syndecan proteoglycan family
Target Research Area
Cancer
Target Synonyms
CD_antigen; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; Sdc1; SDC1_HUMAN; SYND1; Syndecan 1; Syndecan; syndecan proteoglycan 1; Syndecan-1
Target Background
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
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