Recombinant Human Progonadoliberin-2 (GNRH2)

Cat.No	ACP04131	Target Name	GNRH2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	24-120aa	Mol Weight	26.5kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04131

Target Name

GNRH2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

24-120aa

Mol Weight

26.5kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O43555

Background Information

Uniprot Id

O43555
Target Species

Human
Target Name

GNRH2
Target Full Name

Progonadoliberin-2
Target Function

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Target Subcellular Location

Secreted.
Target Protein Families

GnRH family
Target Tissue Specificity

Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.
Target Research Area

Signal Transduction
Target Synonyms

GnRH II; GnRH-associated peptide 2; GnRH-associated peptide II; gnrh2; GON2_HUMAN; Gonadoliberin II; Gonadotropin-releasing hormone 2; Gonadotropin-releasing hormone II; LH-RH II; Luliberin II; Luteinizing hormone-releasing hormone II; Progonadoliberin 2; Progonadoliberin II
Target Background

This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The human GNRH2 gene is predicted to encode a preproprotein from which a mature neuropeptide of 10 amino acids is cleaved. However, while the human genome retains the sequence for a functional GNRH2 decapeptide, translation of the human GNRH2 gene has not yet been demonstrated and the GNRH2 gene of chimpanzees, gorilla, and Sumatran orangutan have a premature stop at codon eight of the decapeptide sequence which suggests GNRH2 was a pseudogene in the hominid lineage. The GNRH2 gene is also believed to be a pseudogene in many other mammalian species such as mouse and cow. The receptor for this gene (GNRHR2) is predicted to be a pseudogene in human as well as many other mammalian species. The closely related GNRH1 and GNRHR1 genes are functional in human and other mammals and are generally functional in vertebrates.

Recombinant Human Progonadoliberin-2 (GNRH2)

Specifications

Immunogen Information

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