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This Recombinant Human CA2 protein is a valuable tool for signal transduction research. Carbonic anhydrase 2 (CA2) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide, playing a crucial role in various physiological processes, including pH regulation, ion transport, and metabolic processes. Its function is essential in multiple research areas, including cellular signal transduction, kidney physiology, and tumor biology. The Recombinant Human CA2 protein provided by us has been meticulously expressed in E. coli, ensuring a consistent and reliable product for your research needs. This full-length protein, spanning the expression region of 2-260aa, represents the entire length of the BC011949 gene, preserving all key functional domains. An N-terminal 6xHis-SUMO tag has been incorporated to facilitate straightforward protein purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human CA2 protein is supplied as a lyophilized powder, offering you a high-quality and dependable tool for your signal transduction research projects.
This Recombinant Human CA2 protein is a valuable tool for signal transduction research. Carbonic anhydrase 2 (CA2) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide, playing a crucial role in various physiological processes, including pH regulation, ion transport, and metabolic processes. Its function is essential in multiple research areas, including cellular signal transduction, kidney physiology, and tumor biology.
The Recombinant Human CA2 protein provided by us has been meticulously expressed in E. coli, ensuring a consistent and reliable product for your research needs. This full-length protein, spanning the expression region of 2-260aa, represents the entire length of the BC011949 gene, preserving all key functional domains. An N-terminal 6xHis-SUMO tag has been incorporated to facilitate straightforward protein purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human CA2 protein is supplied as a lyophilized powder, offering you a high-quality and dependable tool for your signal transduction research projects.
| Cat.No | ACP04150 | Target Name | CA2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-260aa | Mol Weight | 45.1 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P00918 |
|---|
Uniprot Id
P00918
Target Species
Human
Target Name
CA2
Target Full Name
Carbonic anhydrase 2
Target Function
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Target Involvement
Osteopetrosis, autosomal recessive 3 (OPTB3)
Target Subcellular Location
Cytoplasm. Cell membrane. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.
Target Protein Families
Alpha-carbonic anhydrase family
Target Research Area
Signal Transduction
Target Synonyms
CA 2; CA II; CA-II; Ca2; CAC; CAH2_HUMAN; CAII; Car 2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase C; formerly; Carbonic anhydrase II; Carbonic dehydratase; epididymis luminal protein 76; Epididymis secretory protein Li 282; HEL-76; HEL-S-282
Target Background
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.
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