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The expression region of this recombinant Human ADH1B covers amino acids 2-375. This ADH1B protein is expected to have a theoretical molecular weight of 55.7 kDa. This ADH1B recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of ADH1B, making it easier to detect and purify the ADH1B recombinant protein in the later stages of expression and purification.All-trans-retinol dehydrogenase [NAD(+)] ADH1B (ADH1B) is a crucial protein involved in vitamin A metabolism. One of the primary areas of research focuses on the redox role of ADH1B in vitamin A, particularly in the visual process. ADH1B plays a crucial role in generating retinol, which is the active form of vitamin A. The expression and regulation of ADH1B in the retina are highly regarded, as well as its role in maintaining visual function and resisting eye diseases. In addition, ADH1B is associated with some metabolism-related diseases, such as liver diseases, as it participates in the ethanol metabolism pathway, making it a hot topic in alcohol metabolism and liver health research.
The expression region of this recombinant Human ADH1B covers amino acids 2-375. This ADH1B protein is expected to have a theoretical molecular weight of 55.7 kDa. This ADH1B recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of ADH1B, making it easier to detect and purify the ADH1B recombinant protein in the later stages of expression and purification.All-trans-retinol dehydrogenase [NAD(+)] ADH1B (ADH1B) is a crucial protein involved in vitamin A metabolism. One of the primary areas of research focuses on the redox role of ADH1B in vitamin A, particularly in the visual process. ADH1B plays a crucial role in generating retinol, which is the active form of vitamin A. The expression and regulation of ADH1B in the retina are highly regarded, as well as its role in maintaining visual function and resisting eye diseases. In addition, ADH1B is associated with some metabolism-related diseases, such as liver diseases, as it participates in the ethanol metabolism pathway, making it a hot topic in alcohol metabolism and liver health research.
| Cat.No | ACP04171 | Target Name | ADH1B |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-375aa | Mol Weight | 55.7kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P00325 |
|---|
Uniprot Id
P00325
Target Species
Human
Target Name
ADH1B
Target Full Name
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
Target Function
Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Zinc-containing alcohol dehydrogenase family
Target Research Area
Metabolism
Target Synonyms
ADH beta subunit; ADH1B; ADH1B_HUMAN; ADH2; Alcohol dehydrogenase 1B; alcohol dehydrogenase 2 (class I); beta polypeptide; Alcohol dehydrogenase 2; Alcohol dehydrogenase subunit beta; Aldehyde reductase; DKFZp686C06125; OTTHUMP00000220192
Target Background
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene.
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