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Recombinant Human Docking protein 1 (DOK1)

ACP04172

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Specifications

Cat.No	ACP04172	Target Name	DOK1
Target Synonyms	Docking protein 1 62kD ; Docking protein 1; DOK 1; DOK1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-481aa
Mol Weight	68.4kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q99704

Background Information

Uniprot Id

Q99704
Target Species

Human
Target Name

DOK1
Target Full Name

Docking protein 1
Target Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Target Subcellular Location

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm, perinuclear region.
Target Protein Families

DOK family, Type A subfamily
Target Tissue Specificity

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Target Research Area

Cardiovascular
Target Synonyms

Docking protein 1 62kD ; Docking protein 1; DOK 1; DOK1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62
Target Background

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene.

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Recombinant Human Docking protein 1 (DOK1)

Specifications

Immunogen Information

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