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| Cat.No | ACP04274 | Target Name | EDNRA |
|---|---|---|---|
| Target Synonyms | EDNRA; ETA; ETRA; Endothelin-1 receptor; Endothelin receptor type A; ET-A; ETA-R; hET-AR | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 21-80aa |
| Mol Weight | 8.8kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P25101 |
|---|
Uniprot Id
P25101
Target Species
Human
Target Name
EDNRA
Target Full Name
Endothelin-1 receptor
Target Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Target Involvement
Mandibulofacial dysostosis with alopecia (MFDA)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRA sub-subfamily
Target Tissue Specificity
Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and li
Target Research Area
Signal Transduction
Target Synonyms
EDNRA; ETA; ETRA; Endothelin-1 receptor; Endothelin receptor type A; ET-A; ETA-R; hET-AR
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