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The recombinant Human CREB1 was expressed with the amino acid range of 1-341. The expected molecular weight for the CREB1 protein is calculated to be 40.7 kDa. This CREB1 recombinant protein is manufactured in e.coli. The CREB1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant CREB1 protein during the following stages.Human cyclic AMP-responsive element-binding protein 1 (CREB1) is a transcription factor that plays a crucial role in various cellular processes. Upon activation by signaling pathways such as cAMP-dependent pathways, CREB1 undergoes phosphorylation, leading to its binding to cAMP response elements (CREs) in target gene promoters. CREB1 regulates the transcription of genes involved in cell growth, differentiation, survival, and memory formation. Its diverse functions contribute to cellular responses in the nervous system, immune system, and other tissues. Research on CREB1 spans areas such as neurobiology, cancer, metabolism, and circadian rhythms. Understanding CREB1's intricate regulatory role provides insights into fundamental cellular processes and potential therapeutic targets for various diseases.
The recombinant Human CREB1 was expressed with the amino acid range of 1-341. The expected molecular weight for the CREB1 protein is calculated to be 40.7 kDa. This CREB1 recombinant protein is manufactured in e.coli. The CREB1 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant CREB1 protein during the following stages.Human cyclic AMP-responsive element-binding protein 1 (CREB1) is a transcription factor that plays a crucial role in various cellular processes. Upon activation by signaling pathways such as cAMP-dependent pathways, CREB1 undergoes phosphorylation, leading to its binding to cAMP response elements (CREs) in target gene promoters. CREB1 regulates the transcription of genes involved in cell growth, differentiation, survival, and memory formation. Its diverse functions contribute to cellular responses in the nervous system, immune system, and other tissues. Research on CREB1 spans areas such as neurobiology, cancer, metabolism, and circadian rhythms. Understanding CREB1’s intricate regulatory role provides insights into fundamental cellular processes and potential therapeutic targets for various diseases.
| Cat.No | ACP04299 | Target Name | CREB1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-341aa | Mol Weight | 40.7kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P16220 |
|---|
Uniprot Id
P16220
Target Species
Human
Target Name
CREB1
Target Full Name
Cyclic AMP-responsive element-binding protein 1
Target Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Target Involvement
Angiomatoid fibrous histiocytoma (AFH)
Target Subcellular Location
Nucleus.
Target Protein Families
BZIP family
Target Research Area
Immunology
Target Synonyms
Active transcription factor CREB; cAMP response element binding protein 1; cAMP response element binding protein; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; CREB1_HUMAN; Cyclic AMP-responsive element-binding protein 1; MGC9284; OTTHUMP00000163864; OTTHUMP00000163865; OTTHUMP00000206660; OTTHUMP00000206662; OTTHUMP00000206667; Transactivator protein
Target Background
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.
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