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The recombinant Human TSPAN7 was expressed with the amino acid range of 113-213. The theoretical molecular weight of the TSPAN7 protein is 15.6 kDa. Expression of this TSPAN7 protein is conducted in e.coli. The N-terminal 6xHis tag was smoothly integrated into the coding gene of TSPAN7, which enables a simple process of detecting and purifying the TSPAN7 recombinant protein in the following steps.Tetraspanin-7 (TSPAN7) is widely expressed in tissues throughout the body and is particularly prominent in the nervous system. It is a key component of tetraspanin-enriched microdomains (TEMs) or tetraspanin webs, where it interacts with other membrane proteins to regulate signal transduction, cell adhesion, and membrane organization. Research indicates that TSPAN7 plays essential roles in neuronal development and function. It has been implicated in neurite outgrowth, synaptogenesis, and the formation of neuronal circuits. TSPAN7's interactions with other proteins, including integrins and growth factor receptors, suggest its involvement in modulating cell adhesion and signaling pathways critical for neural development. Furthermore, mutations in the TSPAN7 gene have been associated with X-linked intellectual disability (XLID), highlighting its importance in cognitive function.
The recombinant Human TSPAN7 was expressed with the amino acid range of 113-213. The theoretical molecular weight of the TSPAN7 protein is 15.6 kDa. Expression of this TSPAN7 protein is conducted in e.coli. The N-terminal 6xHis tag was smoothly integrated into the coding gene of TSPAN7, which enables a simple process of detecting and purifying the TSPAN7 recombinant protein in the following steps.Tetraspanin-7 (TSPAN7) is widely expressed in tissues throughout the body and is particularly prominent in the nervous system. It is a key component of tetraspanin-enriched microdomains (TEMs) or tetraspanin webs, where it interacts with other membrane proteins to regulate signal transduction, cell adhesion, and membrane organization. Research indicates that TSPAN7 plays essential roles in neuronal development and function. It has been implicated in neurite outgrowth, synaptogenesis, and the formation of neuronal circuits. TSPAN7’s interactions with other proteins, including integrins and growth factor receptors, suggest its involvement in modulating cell adhesion and signaling pathways critical for neural development. Furthermore, mutations in the TSPAN7 gene have been associated with X-linked intellectual disability (XLID), highlighting its importance in cognitive function.
| Cat.No | ACP04457 | Target Name | TSPAN7 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 113-213aa | Mol Weight | 15.6kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P41732 |
|---|
Uniprot Id
P41732
Target Species
Human
Target Name
TSPAN7
Target Full Name
Tetraspanin-7
Target Function
May be involved in cell proliferation and cell motility.
Target Involvement
Mental retardation, X-linked 58 (MRX58)
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Tetraspanin (TM4SF) family
Target Tissue Specificity
Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.
Target Research Area
Immunology
Target Synonyms
A15; CCG B7; CD231; CD231 antigen; Cell surface glycoprotein A15; DXS1692E; Membrane component chromosome X surface marker 1; Membrane component X chromosome surface marker 1; MRX58; MXS1; T cell acute lymphoblastic leukemia associated antigen 1; T-cell acute lymphoblastic leukemia-associated antigen 1; TALLA 1; TALLA; TALLA-1; TALLA1; Tetraspanin 7; Tetraspanin-7; TM4SF2; TM4SF2b; Transmembrane 4 superfamily 2b; Transmembrane 4 superfamily member 2; Transmembrane protein A15; TSN7_HUMAN; Tspan 7; Tspan-7; TSPAN7
Target Background
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked cognitive disability and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.
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