Recombinant Human Innate immunity activator protein (INAVA)

Uniprot Id

Q3KP66

Target Species

Human

Target Name

INAVA

Target Full Name

Innate immunity activator protein

Target Function

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Tissue Specificity

Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation.

Target Research Area

Cell Biology

Target Synonyms

C1orf106; CA106_HUMAN; Chromosome 1 open reading frame 106 ; FLJ10901; Uncharacterized protein C1orf106