Recombinant Human Thyroid hormone receptor beta (THRB)

Cat.No	ACP04831	Target Name	THRB
Target Synonyms	avian), beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-461aa
Mol Weight	68.8kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04831

Target Name

THRB

Target Synonyms

avian), beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-461aa

Mol Weight

68.8kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P10828

Background Information

Uniprot Id

P10828
Target Species

Human
Target Name

THRB
Target Full Name

Thyroid hormone receptor beta
Target Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Target Involvement

Generalized thyroid hormone resistance (GTHR); Generalized thyroid hormone resistance autosomal recessive (GTHRAR); Selective pituitary thyroid hormone resistance (PRTH)
Target Subcellular Location

Nucleus.
Target Protein Families

Nuclear hormone receptor family, NR1 subfamily
Target Research Area

Cardiovascular
Target Synonyms

Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2; C ERBA 2; C ERBA BETA; c-erbA-2; c-erbA-beta; ERBA 2; ERBA BETA; ERBA2; Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian; generalized resistance to thyroid hormone; GRTH; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; Oncogene ERBA2; PRTH; THB_HUMAN; THR1; THRB 1; THRB 2; thrB; THRB1; THRB2; Thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor beta 1; Thyroid hormone receptor beta 2; Thyroid hormone receptor beta; Thyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian)
Target Background

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Recombinant Human Thyroid hormone receptor beta (THRB)

Specifications

Immunogen Information

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