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| Cat.No | ACP05058 | Target Name | YJEFN3 |
|---|---|---|---|
| Target Synonyms | YJEFN3; YjeF N-terminal domain-containing protein 3; YjeF_N3; hYjeF_N3 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-299aa |
| Mol Weight | 32.6 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A6XGL0 |
|---|
Uniprot Id
A6XGL0
Target Species
Human
Target Name
YJEFN3
Target Full Name
YjeF N-terminal domain-containing protein 3
Target Function
May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence. May play a role in spermiogenesis and oogenesis.
Target Tissue Specificity
Expressed in theca cells in ovary and in Leydig cells in testis (at protein level). Also expressed in brain and mammary gland.
Target Research Area
Others
Target Synonyms
YJEFN3; YjeF N-terminal domain-containing protein 3; YjeF_N3; hYjeF_N3
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