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The gene encoding the Human FSHR protein (18-366aa) is inserted into a plasmid vector to form the recombinant plasmid, which is introduced into baculovirus cells. baculovirus cells that have successfully taken up the recombinant plasmid can be selected based on their ability to survive in the presence of a specific antibiotic. The recombinant plasmid-containing baculovirus cells are cultured under conditions that promote the expression of the interested gene. The protein is fused with a N-terminal 6xHis tag. After expression, the recombinant Human FSHR protein is isolated and purified from the cell lysate through affinity purification. The resulting recombinant Human FSHR protein is resolved by denaturing SDS-PAGE, allowing its purity to be estimated, greater than 85%.
The gene encoding the Human FSHR protein (18-366aa) is inserted into a plasmid vector to form the recombinant plasmid, which is introduced into baculovirus cells. baculovirus cells that have successfully taken up the recombinant plasmid can be selected based on their ability to survive in the presence of a specific antibiotic. The recombinant plasmid-containing baculovirus cells are cultured under conditions that promote the expression of the interested gene. The protein is fused with a N-terminal 6xHis tag. After expression, the recombinant Human FSHR protein is isolated and purified from the cell lysate through affinity purification. The resulting recombinant Human FSHR protein is resolved by denaturing SDS-PAGE, allowing its purity to be estimated, greater than 85%.
| Cat.No | ACP05198 | Target Name | FSHR |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Baculovirus |
| Expression Range | 18-366aa | Mol Weight | 41.0 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P23945 |
|---|
Uniprot Id
P23945
Target Species
Human
Target Name
FSHR
Target Full Name
Follicle-stimulating hormone receptor
Target Function
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
Target Involvement
Ovarian dysgenesis 1 (ODG1); Ovarian hyperstimulation syndrome (OHSS)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
Target Tissue Specificity
Sertoli cells and ovarian granulosa cells.
Target Research Area
G-protein coupled receptor, Neuroscience
Target Synonyms
Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; Fshr; FSHR_HUMAN; FSHRO; LGR1; MGC141667; MGC141668; ODG1; ovarian dysgenesis 1
Target Background
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
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