Recombinant Human Hemoglobin subunit gamma-1 (HBG1)

Uniprot Id

P69891

Target Species

Human

Target Name

HBG1

Target Full Name

Hemoglobin subunit gamma-1

Target Function

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Target Protein Families

Globin family

Target Tissue Specificity

Red blood cells.

Target Research Area

Signal Transduction

Target Synonyms

HBG1; PRO2979; Hemoglobin subunit gamma-1; Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain

Target Background

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.